Pesquisa | SciELO

Precisa de ajuda?

Adicionar outro campo +

Histórico de busca

Não foram encontrados documentos para sua pesquisa

Resultados: 25

au:"Moreira, Regina Célia"

Filtros

Coleções + Opções

Todos
Brasil

22
Saúde Pública

3

Periódico + Opções

Todos
Revista da Sociedade Brasileira de Medicina Tropical

5
Memórias do Instituto Oswaldo Cruz

4
Revista Brasileira de Epidemiologia

4
Revista do Instituto de Medicina Tropical de São Paulo

4
Brazilian Journal of Infectious Diseases

3
Epidemiologia e Serviços de Saúde

2
Jornal Brasileiro de Patologia e Medicina Laboratorial

1
Revista da Associação Médica Brasileira

1
Sao Paulo Medical Journal

1

Idioma

Todos
Português

5

Ano de publicação + Opções

Todos
2020

4
2012

3
2014

3
2018

3
2005

2
2019

2
1998

1
2000

1
2007

1
2010

1
2013

1
2016

1
2021

1
2022

1

SciELO Áreas Temáticas + Opções

Todos
Ciências da Saúde

25
Ciências Biológicas

11

WoS Áreas Temáticas + Opções

Todos
Medicine

17
Tropical

13
Health

6
Diseases

4
Infectious

4
Parasitologia

4
Policy

4
Services

4
General

3
Internal

3
Care

2
Environmental

2
Occupational

2
Public

2
Sciences

2

Mostrar tudo...

WoS Índice de Citações

Todos
Science Citation Index Expanded

18

Citáveis e não citáveis

Todos
Citável

25

Tipo de literatura + Opções

Todos
Artigo

22
Comunicação rápida

3

Ordenar por

Página de 2 Próxima

Selecionar esta página

Imprimir | Enviar por e-mail | Exportar |

Facebook
Twitter
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

0 Itens selecionados

Listar itens
Apagar todos da lista

Characterization of primary direct-acting antiviral (DAA) drugs resistance mutations in NS5A/NS5B regions of hepatitis C virus with genotype 1a and 1b from patients with chronic hepatitis
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Ana Paula de Torres

; Silva, Vanessa Cristina Martins

; Mendes-Corrêa, Maria Cássia

; Lemos, Marcilio Figueiredo

; Malta, Fernanda de Mello

; Santana, Rúbia Anita Ferraz

; Dastoli, Gregório Tadeu Fernando

; Castro, Vanessa Fusco Duarte de

; Pinho, João Renato Rebello

; Moreira, Regina Célia

Revista do Instituto de Medicina Tropical de São Paulo

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2022, Volume 64 elocation e61

Resumo: En | Texto: En | PDF: En

ABSTRACT The Hepatitis C virus (HCV) infection is a public health problem. The high level of HCV replication and its lack of post-transcriptional correction mechanisms results in the emergence of viral variants and the difficulty in determining polymorphisms and variants that contain the substitutions associated with resistance towards new antivirals. The main focus of this study was to map the NS5A and NS5B polymorphisms and resistance mutations to new antiviral drugs in HCV strains genotype 1 from patients with chronic hepatitis C infection. Serum samples were collected from patients who underwent routine viral load tests at the Instituto Adolfo Lutz, Sao Paulo city, Brazil. A total of 698 and 853 samples were used for the characterization of NS5A and NS5B regions, respectively, which comprise the HCV genotypes 1a and 1b. The prevalence of resistance mutations found in the NS5A region was 6.4%, with Y93H, L31M, Q30R, and Y93N as the main resistance-associated substitutions (RAS). No NS5B-associated RAS was observed for any of the analyzed drugs. These findings support that the RAS test should be offered to individuals with poor response to double combination regimens prior to treatment initiation, thereby assisting strain vigilance and selection of effective treatment or retreatment options using DAA regimens.

https://doi.org/10.1590/s1678-9946202264061

Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Meneghello, Brígida Helena da Silva

; Soares, Márcia Maria Costa Nunes

; Silva, Vanessa Cristina Martins

; Lemos, Marcilio Figueiredo

; Cervato, Murilo Castro

; Caetano Filho, João

; Sitnik, Roberta

; Estécio, Tânia Cristina Higino

; Compri, Adriana Parise

; Pinho, João Renato Rebello

; Moreira, Regina Célia

Revista do Instituto de Medicina Tropical de São Paulo

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2021, Volume 63 elocation e78

Resumo: En | Texto: En | PDF: En

ABSTRACT In Brazil, few studies on the molecular aspects of hepatitis B virus (HBV) infection have been conducted in the interior regions of Sao Paulo State. This study aimed to identify HBV genotypes and evaluate strains with resistance mutations for nucleoside analogues in the Administrative Region (AR) of the municipality of Sao Jose do Rio Preto. We performed nested PCRs of 127 samples from the Health Care Services of the AR to amplify, sequence and analyze fragments of the HBV DNA, in order to identify genotypes and resistance mutations. The HBV S/Pol regions of 126 samples were successfully amplified and sequenced. Five different genotypes were found, and the main ones were A, D and F; a greater number of samples contained the subgenotypes A1 (n = 51; 40.5%), D3 (n = 36; 28.6%), A2 (n = 14; 11.1%) and F2a (n = 9; 7.1%). Resistance mutations (rtM204V/I/S) associated or not with compensatory mutations (rtL180M, rtV173L) were identified in 13.9% (5/36) of patients undergoing viral treatment and 1.1% (1/90) of naïve patients. The diversity of genotypes/subgenotypes found is probably due to the intense migration occurring in the region. These data can complement epidemiological and clinical surveillance, and can be used for a more effective management of chronic HBV patients.

https://doi.org/10.1590/s1678-9946202163078 54 downloads

Ocorrência de hepatite B em gestantes e seguimento de crianças expostas no estado de São Paulo, em 2012
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Farias, Norma Suely de Oliveira

; Holcman, Marcia Moreira

; Compri, Adriana Parise

; Silva, Célia Regina Cicolo da

; Figueiredo, Gerusa Maria

; Moreira, Regina Célia

; Pinho, Maria Eunice Rebello

; Bersusa, Ana Aparecida Sanches

; Coelho, Débora Moraes

; Koizumi, Inês Kazue

; Sato, Helena Keico

; Araujo, Núbia Virginia D’Avila Limeira de

; Caminada, Sirlene

Epidemiologia e Serviços de Saúde

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2020, Volume 29 Nº 2 elocation e2019443

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo: descrever a ocorrência da hepatite B entre gestantes, a realização de imunoprofilaxia e a transmissão vertical e perinatal nas crianças expostas ao vírus na rede de Atenção Primária à Saúde do estado de São Paulo, Brasil. Métodos: estudo transversal sobre registros de pré-natal de gestantes atendidas de janeiro a junho de 2012 e coorte dos recém-nascidos; foram descritas as frequências dos resultados e calculada a estimativa da ocorrência da hepatite B. Resultados: foram incluídas 6.233 gestantes, das quais 53,1% com 20 a 29 anos de idade, 58,7% com 8 a 11 anos de estudo, 53,3% brancas e 73,9% com companheiro; a ocorrência de hepatite B foi de 0,13% (IC95%: 0,04 a 0,21%); das oito crianças de mães com hepatite B crônica, seis tiveram esquema vacinal completo e não houve transmissão vertical ou perinatal. Conclusão: observou-se baixa ocorrência de hepatite B em gestantes e ausência de transmissão vertical ou perinatal.

Abstract Objective: to describe the occurrence of hepatitis B among pregnant women, immunoprophylaxis and vertical and perinatal transmission in children exposed to the virus in the São Paulo state primary care network, Brazil. Methods: this was a cross-sectional study using prenatal records of pregnant women attending health services between January and June 2012 and a cohort of newborns; the frequencies of the results were described and the estimated occurrence of hepatitis B was calculated. Results: 6,233 pregnant women were included, of whom 53.1% were between 20-29 years old, 58.7% had 8-11 years of schooling, 53.3% were white, and 73.9% lived with a partner; occurrence of hepatitis B was 0.13% (95%CI 0.04; 0.21); of the eight children of mothers with chronic hepatitis B, six had a complete vaccination schedule, and there was no vertical or perinatal transmission. Conclusion: there was low occurrence of hepatitis B in pregnant women and absence of vertical or perinatal transmission.

Resumen Objetivo: describir el aparecimiento de hepatitis B en mujeres embarazadas, la inmunoprofilaxis y la transmisión vertical y perinatal en niños expuestos al virus en la red de atención primaria en el estado de São Paulo, Brasil. Métodos: estudio transversal con registros prenatales de mujeres embarazadas atendidas de enero a junio de 2012 y cohorte de recién nacidos; se describieron las frecuencias y se calculó el surgimiento de la hepatitis B. Resultados: se incluyeron 6.233 gestantes, de las cuales 53,1% con 20 a 29 años de edad, 58,7% con 8 a 11 años de estudios, 53,3% blancas y 73,9% viviendo en pareja; la ocurrencia de hepatitis B fue del 0,13% (IC95%: 0,04 to 0,21%); entre ocho hijos de madres con hepatitis B crónica, seis tenía un calendario de vacunación completo y no había transmisión vertical o perinatal. Conclusión: hubo baja ocurrencia de hepatitis B en mujeres embarazadas y ausencia de transmisión vertical o perinatal.

https://doi.org/10.5123/s1679-49742020000200018

Surveillance of human retroviruses in blood samples from patients with hepatitis B and C in São Paulo, Brazil
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Caterino-de-Araujo, Adele

; Campos, Karoline Rodrigues

; Petrucci, Tamirez Villas Boas

; Silva, Rafael Xavier da

; Lemos, Marcílio Figueiredo

; Moreira, Regina Célia

Revista da Sociedade Brasileira de Medicina Tropical

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2020, Volume 53 elocation e20190378

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION Human retroviruses and the hepatitis B and C viruses (HBV and HCV, respectively) share routes of transmission; thus, coinfections occur and could alter subsequent disease outcomes. A preliminary study on human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in serum samples from HBV- and HCV-infected individuals in São Paulo revealed 1.3% and 5.3% rates of coinfection, respectively. These percentages were of concern since they were detected in HTLV-endemic regions and in high-risk individuals in Brazil. The present study was conducted to extend and confirm these data. METHODS HTLV-1/2 and human immunodeficiency virus (HIV) infection status were identified in 1,984 sera for HBV and HCV viral load quantification - 1,290 samples from HBV-infected individuals (53.3% men, mean age: 47.1 years) and 694 samples from HCV-infected individuals (56.3% men, mean age: 50.1 years). HTLV-1/2 antibodies were detected by enzyme immunoassay, followed by western blotting and line immunoassay; HIV infection was detected by enzyme immunoassay. RESULTS HTLV-1/-2 infection was detected in 1.9% HBV-infected individuals (0.7% HTLV-1 and 1.2% HTLV-2) and in 4.0% (2.4% HTLV-1 and 1.6% HTLV-2) HCV-infected individuals; HIV infection was detected in 9.2% and 14.5%, respectively. Strong associations with HTLV and HIV, male sex, and older age were found in HBV/HTLV and HCV/HTLV-coinfected individuals (p<0.05). CONCLUSIONS HTLV-1 and HTLV-2 were confirmed to be prevalent in individuals with HBV and HCV in São Paulo; coinfected individuals deserve further clinical and laboratory investigation.

https://doi.org/10.1590/0037-8682-0378-2019 1228 downloads

Ocorrência de hepatite B em gestantes e seguimento de crianças expostas no estado de São Paulo, em 2012
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Farias, Norma Suely de Oliveira

; Holcman, Marcia Moreira

; Compri, Adriana Parise

; Silva, Célia Regina Cicolo da

; Figueiredo, Gerusa Maria

; Moreira, Regina Célia

; Pinho, Maria Eunice Rebello

; Bersusa, Ana Aparecida Sanches

; Coelho, Débora Moraes

; Koizumi, Inês Kazue

; Sato, Helena Keico

; Araujo, Núbia Virginia D’Avila Limeira de

; Caminada, Sirlene

Epidemiologia e Serviços de Saúde

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2020, Volume 29 Nº 2 elocation e2019443

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.5123/s1679-49742020000200018 1043 downloads

Hepatitis B: Prevalence and occult infection in HIV-infected patients
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Calux, Samira Julien

; Silva, Vanessa Cristina Martins

; Compri, Adriana Parise

; Lemos, Marcílio Figueiredo

; Santos, Ana Paula de Torres

; Oba, Isabel Takano

; Mendes-Correa, Maria Cássia J.

; Moreira, Regina Célia

Revista da Sociedade Brasileira de Medicina Tropical

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2020, Volume 53 elocation e20180533

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: HBV and HIV have identical transmission routes. The aim of this study was to determine the prevalence of HBV in HIV patients and to detect the presence of occult HBV infection. METHODS: All samples were tested for serology markers and using qPCR. RESULTS: This study included 232 individuals, out of which 36.6% presented with HBV markers and 11.8% presented with HBsAg or HBV-DNA, including 3 patients that showed OBI. CONCLUSIONS: We observed a high prevalence of HBV among HIV patients. In addition, the results suggest that OBI can occur in patients with serological profiles that are indicative of past infection. Therefore, the application of molecular tests may enable the identification of infections that are not evident solely based on serology.

https://doi.org/10.1590/0037-8682-0533-2018 598 downloads

The 12 city HIV Surveillance Survey among MSM in Brazil 2016 using respondent-driven sampling: a description of methods and RDS diagnostics
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Kendall, Carl

; Kerr, Ligia

; Mota, Rosa Salani

; Guimarães, Mark Drew Crosland

; Leal, Andrea Fachel

; Merchan-Hamann, Edgar

; Dourado, Inês

; Veras, Maria Amélia

; Brito, Ana Maria de

; Pontes, Alexandre Kerr

; Motta-Castro, Ana Rita Coimbra

; Macena, Raimunda Hermelinda Maia

; Knauth, Daniela

; Lima, Luana Nepomuceno Gondim Costa

; Oliveira, Lisangela Cristina

; Cavalcante, Socorro

; Camillo, Ana Cláudia

; Bermudez, Ximena Pamela Diaz

; Moreira, Regina Célia

; Benzaken, Adele Schwartz

; Pereira, Gerson

; Pascom, Ana Roberta Pati

; Pimenta, Cristina

; Grazina Johnston, Lisa

Revista Brasileira de Epidemiologia

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2019, Volume 22 elocation e190004

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Introdução: Este artigo detalha os métodos utilizados na segunda Pesquisa Nacional de Vigilância Biológica e Comportamental (BBSS) do HIV, sífilis e hepatite B e C entre os homens que fazem sexo com homens no Brasil. Métodos: O método Respondent-driven Sampling (RDS) foi utilizado em 12 cidades em 2016. A amostra foi iniciada com cinco a seis sementes em cada cidade. Testes rápidos para o HIV, sífilis e Hepatite B e C foram oferecidos aos participantes. O software RDS Analyst com o estimador de amostragem sucessiva (SS) de Gile foi utilizado para ajustar os resultados como recomendado, gerando um peso para cada indivíduo para análises. Osdados das 12cidades foram unidos em um único banco e analisados usando as ferramentas de dados complexos do Stata 14.0, com cada cidade sendo tratada como seu próprio estrato. Resultados: A duração da coleta de dados variou de 5,9 a 17,6 semanas e 4.176 homens foram recrutados nas 12 cidades. Dois sites não alcançaram o tamanho da amostra alvo devido a uma demora de seis meses na aprovação local do Comitê de Ética. Todas as cidades atingiram a convergência na principal variável estudada (HIV). Conclusão: O BBSS foi representativo e concluído conforme planejado e dentro do orçamento. A descrição dos métodos aqui é mais detalhada do que o habitual, devido às novas ferramentas e requisitos de diagnóstico das novas diretrizes do STROBE-RDS.

ABSTRACT: Introduction: This paper details the methods used in the second national Biological and Behavioral Surveillance Survey (BBSS) of HIV, syphilis, and hepatitis B and C among men who have sex with men in Brazil. Methods: Respondent-driven sampling (RDS) was used in 12 cities in 2016. The targeted sample size was initiated with five to six seeds in each city. HIV, syphilis, and Hepatitis B and C rapid tests were offered to participants. RDS Analyst with Gile’s successive sampling (SS) estimator was used to adjust results as recommended and a weight for each individual was generated for further analysis. Data for the 12 cities were merged and analyzed using Stata 14.0 complex survey data tools with each city treated as its own stratum. Results: Duration of data collection varied from 5.9 to 17.6 weeks. 4,176 men were recruited in the 12 cities. Two sites failed to achieve targeted sample size due to a six-month delay in local IRB approval. No city failed to reach convergence in our major outcome variable (HIV). Conclusion: The comprehensive BBSS was completed as planned and on budget. The description of methods here is more detailed than usual, due to new diagnostic tools and requirements of the new STROBE-RDS guidelines.

https://doi.org/10.1590/1980-549720190004

The 12 city HIV Surveillance Survey among MSM in Brazil 2016 using respondent-driven sampling: a description of methods and RDS diagnostics
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Kendall, Carl

; Kerr, Ligia

; Mota, Rosa Salani

; Guimarães, Mark Drew Crosland

; Leal, Andrea Fachel

; Merchan-Hamann, Edgar

; Dourado, Inês

; Veras, Maria Amélia

; Brito, Ana Maria de

; Pontes, Alexandre Kerr

; Motta-Castro, Ana Rita Coimbra

; Macena, Raimunda Hermelinda Maia

; Knauth, Daniela

; Lima, Luana Nepomuceno Gondim Costa

; Oliveira, Lisangela Cristina

; Cavalcante, Socorro

; Camillo, Ana Cláudia

; Bermudez, Ximena Pamela Diaz

; Moreira, Regina Célia

; Benzaken, Adele Schwartz

; Pereira, Gerson

; Pascom, Ana Roberta Pati

; Pimenta, Cristina

; Grazina Johnston, Lisa

Revista Brasileira de Epidemiologia

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

2019, Volume 22 elocation e190004

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720190004 2719 downloads

Fluctuations in serological hepatitis C virus levels in HIV patients
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Silva, Vanessa Cristina Martins

; Calux, Samira Julien

; Lemos, Marcilio Figueiredo

; Compri, Adriana Parise

; Santos, Ana Paula de Torres

; Oba, Isabel Takano

; Mendes-Correa, Maria Cássia Jacintho

; Moreira, Regina Célia

Revista da Sociedade Brasileira de Medicina Tropical

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Dez 2018, Volume 51 Nº 6 Páginas 737 - 741

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) have identical transmission routes, explaining the high prevalence of coinfections. The main aim of this study was to detect fluctuations in serological HCV levels in HIV patients. METHODS: We analyzed samples of 147 patients who attended an outpatient service that supports HIV/AIDS patients in São Paulo city. We also recruited 22 HCV-monoinfected patients who attended the Instituto Adolfo Lutz Laboratory in São Paulo city, to compare the test results. Serological testing of the blood samples was performed for the detection of HCV antibodies. The samples were then analyzed using real-time PCR for RNA viral quantification and sequencing. RESULTS We found that 13.6% of the study population was coinfected with HIV and HCV. In 20% of coinfected patients, fluctuations in serology results were detected in samples collected during the follow-up. No changes in anti-HCV serological markers were observed in HCV-monoinfected patients. An HCV viral load was detected in 9,5% of the samples collected from HIV patients. CONCLUSIONS: Our findings provide important clinical data to public health professionals and highlight the importance of periodic monitoring of HCV/HIV coinfected patients.

https://doi.org/10.1590/0037-8682-0239-2018 1024 downloads

10.

Hepatitis C viral load in HCV-monoinfected and HCV/HIV-1-, HCV/HTLV-1/-2-, and HCV/HIV/HTLV-1/-2-co-infected patients from São Paulo, Brazil
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Alves, Fabiana Aparecida

; Campos, Karoline Rodrigues

; Lemos, Marcílio Figueiredo

; Moreira, Regina Célia

; Caterino-de-Araujo, Adele

Brazilian Journal of Infectious Diseases

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Mar 2018, Volume 22 Nº 2 Páginas 123 - 128

Resumo: En | Texto: En | PDF: En

ABSTRACT Co-infections of hepatitis C virus (HCV) and either human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotropic virus type 1 (HTLV-1) or type 2 (HTLV-2) have been described as having an impact on HCV viremia and subsequent disease progression. HCV load in serum samples from 622 patients (343 males, 279 females; median age 50.8 years) from São Paulo/southeast Brazil was analyzed using the Abbott Real Time HCV assay (Abbott Molecular Inc., IL, USA). Samples were obtained from HCV-monoinfected (n = 548), HCV/HIV-1- (n = 41), HCV/HTLV-1- (n = 16), HCV/HTLV-2- (n = 8), HCV/HIV/HTLV-1- (n = 4), and HCV/HIV/HTLV-2-co-infected (n = 5) patients, and results were compared among the groups and according to sex. The median HCV load in HCV-monoinfected patients was 5.23 log10 IU/mL and 0.31 log10 higher in men than in women. Increases in viral load of 0.51 log10, 0.54 log10, and 1.43 log10 IU/mL were detected in HCV/HIV-1-, HCV/HTLV-1- and HCV/HIV/HTLV-1-co-infected individuals, respectively, compared with HCV-monoinfected counterparts. In contrast, compared to HCV/HIV co-infected patients, HCV/HTLV-2-co-infected patients had an HCV load of 5.0 log10 IU/mL, whereas HCV/HIV/HTLV-2-co-infected patients had a median load 0.37 log10 IU/mL lower. Significant differences in HCV loads were detected, with males and HCV/HIV-1- and HCV/HIV/HTLV-1-co-infected patients presenting the highest values. Conversely, females and HCV/HTLV-2-co-infected patients exhibited lower HCV loads. Overall, HCV viremia is increased in HIV and/or HTLV-1-co-infection and decreased in HTLV-2 co-infection.

https://doi.org/10.1016/j.bjid.2018.03.002 524 downloads

11.

Making the invisible visible: searching for human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in Brazilian patients with viral hepatitis B and C
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Caterino-de-Araujo, Adele

; Alves, Fabiana Aparecida

; Campos, Karoline Rodrigues

; Lemos, Marcílio Figueiredo

; Moreira, Regina Célia

Memórias do Instituto Oswaldo Cruz

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Fev 2018, Volume 113 Nº 2 Páginas 130 - 134

Resumo: En | Texto: En | PDF: En

With this study, the authors hope to alert clinicians regarding the presence of human T-cell lymphotropic virus type 1 and 2 (HTLV-1/-2) infections in patients with viral hepatitis B and C in Brazil. HTLV-1/-2 were detected in 1.3% of hepatitis B virus (HBV)- and 5.3% of hepatitis C virus (HCV)-infected blood samples sent for laboratory viral load measurements. A partial association of human immunodeficiency virus (HIV)-1 and HTLV-1/-2 infection was detected in patients with HCV (HIV+, 27.3%), whereas this association was almost 100% in HBV-infected patients (HIV+, all except one). The high prevalence of HTLV-1/-2 infection among patients with hepatitis C was of concern, as HTLV-1/-2 could change the natural course of subsequent liver disease. The authors suggest including HTLV-1/-2 serology in the battery of tests used when following patients with viral hepatitis in Brazil, regardless of the HIV status.

https://doi.org/10.1590/0074-02760170307 1384 downloads

12.

An in-house real-time polymerase chain reaction: standardisation and comparison with the Cobas Amplicor HBV monitor and Cobas AmpliPrep/Cobas TaqMan HBV tests for the quantification of hepatitis B virus DNA
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Ana Paula de Torres

; Levi, José Eduardo

; Lemos, Marcilio Figueiredo

; Calux, Samira Julien

; Oba, Isabel Takano

; Moreira, Regina Célia

Memórias do Instituto Oswaldo Cruz

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Fev 2016, Volume 111 Nº 2 Páginas 134 - 140

Resumo: En | Texto: En | PDF: En

This study aimed to standardise an in-house real-time polymerase chain reaction (rtPCR) to allow quantification of hepatitis B virus (HBV) DNA in serum or plasma samples, and to compare this method with two commercial assays, the Cobas Amplicor HBV monitor and the Cobas AmpliPrep/Cobas TaqMan HBV test. Samples from 397 patients from the state of São Paulo were analysed by all three methods. Fifty-two samples were from patients who were human immunodeficiency virus and hepatitis C virus positive, but HBV negative. Genotypes were characterised, and the viral load was measure in each sample. The in-house rtPCR showed an excellent success rate compared with commercial tests; inter-assay and intra-assay coefficients correlated with commercial tests (r = 0.96 and r = 0.913, p < 0.001) and the in-house test showed no genotype-dependent differences in detection and quantification rates. The in-house assay tested in this study could be used for screening and quantifying HBV DNA in order to monitor patients during therapy.

https://doi.org/10.1590/0074-02760150415 1487 downloads

13.

Identification of hepatitis B virus genotypes in the state of São Paulo
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Ana Paula de Torres

; Levi, José Eduardo

; Lemos, Marcílio Figueiredo

; Calux, Samira Julien

; Oba, Isabel Takano

; Moreira, Regina Célia

Revista da Associação Médica Brasileira

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Out 2014, Volume 60 Nº 5 Páginas 424 - 427

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Objetivo: o objetivo deste estudo foi identificar os genótipos do HBV nas amostras de soros recebidas pelo Laboratório de Hepatites do Centro de Virologia do Instituto Adolfo Lutz. Métodos: foram analisadas aleatoriamente 94 amostras de soropositivas, provenientes de diversos municípios do Estado de São Paulo. Para determinação dos genótipos, foi realizada Nested-PCR das regiões S e Pol do HBV. Os genótipos foram identificados comparando os resultados amplificados com as sequências depositadas no GenBank. Resultados: foi possível determinar o genótipo de 91 (97%) amostras do total analisado e os genótipos identificados foram: genótipos A (55,3%), D (32%), F (5,3%), C (3,2%) e G (1%). Há poucos dados a respeito da epidemiologia do genótipo G. Esse genótipo tem sido detectado em áreas restritas do mundo. Geralmente, a infecção pelo genótipo G ocorre em indivíduos HIV positivos do sexo masculino. Neste trabalho, a amostra identificada como G foi também positiva para HIV e era de uma paciente do sexo feminino, dado raro na literatura científica. Conclusão: neste trabalho, foram identificados os genótipos mais frequentes, assim como uma cepa do genótipo G, rara entre os encontrados em nosso meio.

Objective: the aim of this study was to identify HBV genotypes in serum samples from patients from the state of São Paulo, received by the viral hepatitis laboratory, at the Virology Centre of Instituto Adolfo Lutz, from various municipalities. Methods: a total of 94 serum samples were randomly analyzed. Genotyping was performed using nested PCR for amplification of S and Pol regions from viral genome. Genotypes were identified comparing the sequences obtained with the sequences deposited in GenBank. Results: we were able to determine the genotype of 91 (97%) samples, as follows: genotype A (55.3%), D (32%), F (5.3%), C (3.2%) and G (1%). There are few data on the epidemiology of genotype G. This genotype has been detected in restricted areas around the world. Frequently, the genotype G infection occurs in HIV-positive male patients. In our case, the sample identified as G was also positive for HIV but in a female patient, which is an uncommon finding in the scientific literature. Conclusion: in this work, we identified the most frequent genotypes in São Paulo as well as the genotype G, rare among the genotypes found in our environment.

https://doi.org/10.1590/1806-9282.60.05.009 25315 downloads

14.

Epidemiological, serological and molecular aspects of hepatitis B and C in children and teenagers of municipal daycare facilities schools and schools in the city of Santos
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Ciaccia, Maria Célia Cunha

; Moreira, Regina Célia

; Lemos, Marcílio Figueiredo

; Oba, Isabel Takano

; Porta, Gilda

Revista Brasileira de Epidemiologia

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Set 2014, Volume 17 Nº 3 Páginas 588 - 599

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Objetivo: Estimar a prevalência de marcadores sorológicos anti-HBc, AgHBs e anti-HBs da hepatites B e anti-HCV da hepatite C em crianças e adolescentes matriculados em creches e escolas de ensino infantil e fundamental da rede municipal na cidade de Santos, São Paulo. Métodos: Estudo transversal realizado no período de 28 de junho a 14 de dezembro de 2007, no qual foram coletadas 4.680 amostras de sangue colhidas através de punção capilar. Foi aplicado um questionário nos familiares das crianças e adolescentes. Para o cálculo da amostra, foi utilizado o programa Epi Info versão 6 com frequência esperada de 1%, erro aceitável de 0,5% e nível de confiança de 95%. Os exames sorológicos foram realizados utilizando a técnica de ELISA. O estudo molecular foi realizado pela técnica de reação em cadeia de polimerase in House. Resultados: A idade da população estudada variou de 7 meses a 18 anos e 1 mês. A prevalência geral do anti-HBc reagente foi de 0,1%, do AgHBs foi de 0,02% e do anti-HCV foi de 0,02%. Conclusão: A prevalência geral em crianças dos marcadores sorológicos para hepatites B e C na cidade de Santos foi baixa, quando comparada com os dados de literatura.

Objective: To estimate the prevalence of the serological markers anti-HBc, HBsAg and anti-HBs of hepatitis B and anti-HCV of hepatitis C among children and teenagers enrolled at daycare facilities, kindergartens and municipal elementary education network in the city of Santos, São Paulo, Brazil. Methods: A cross-sectional study was carried out from June 28 to December 14, 2007, in which 4,680 finger-prick blood samples were collected from children and teenagers. A survey questionnaire was applied to their family members. The sample was dimensioned using the software Epi Info version 6 with expected frequency of 1%, acceptable error of 0.5% and confidence interval of 95%. The serological tests were performed using the ELISA technique. The molecular analysis was performed using the technique of polymerase chain reaction in House. Results: Age of the studied population ranged from 7 months to 18 years and 1 month. The general prevalence of anti-HBc reagent was 0.1%, HBsAg was 0.02% and anti-HCV was 0.02%. Conclusions: In children, the general prevalence of serological markers for hepatitis B and C in the city of Santos was low when compared with literature data.

https://doi.org/10.1590/1809-4503201400030002 3953 downloads

15.

Epidemiological, serological and molecular aspects of hepatitis B and C in children and teenagers of municipal daycare facilities schools and schools in the city of Santos
Facebook Twitter

Outras redes sociais
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Outras redes

Métricas
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Ciaccia, Maria Célia Cunha

; Moreira, Regina Célia

; Lemos, Marcílio Figueiredo

; Oba, Isabel Takano

; Porta, Gilda

Revista Brasileira de Epidemiologia

Métricas do periódico
- Sobre o periódico
- SciELO Analytics

Set 2014, Volume 17 Nº 3 Páginas 588 - 599

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1809-4503201400030002 1286 downloads

Exibindo

itens por página

Página de 2 Próxima

Selecione um ou mais resultados

Todos Ordem alfabética

Resultados

Gráfico comparativo Download CSV

Visualizar estatísticas de

Enviar resultado

E-mail do(s) destinatários*

Utilize ; (ponto e vírgula) para mais de um e-mail.

Enviar por e-mail

Esta página

Registros selecionados

Todos os registros (max. 300)

Alterar remetente, assunto e comentários

Seu email

Assunto

Comentários

Alterar remetente, assunto e comentários

Exportar resultados

Formato de exportação:

RIS (para EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citação

CSV (para Excel, etc)

Exportar:

Esta página

Itens selecionados

Todos os registros (max. 2000)

Mostrar mais

Sem resultados

Não foram encontrados documentos para sua pesquisa

Glossário e ajuda para busca

Você pode enriquecer sua busca de uma forma muito simples. Use os índices de pesquisa combinados com os conectores (AND ou OR) e especifique cada vez mais sua busca.

Por exemplo, se você deseja buscar artigos sobre
casos de dengue no Brasil em 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

Veja abaixo a lista completa de índices de pesquisa que podem ser usados:

Cód. do Índice	Elemento
ti	título do artigo
au	autor
kw	palavras-chave do artigo
subject	assunto (palavras do título, resumo e palavras-chave)
ab	resumo
ta	título abreviado da revista (ex. Cad. Saúde Pública)
journal_title	título completo da revista (ex. Cadernos de Saúde Pública)
la	código do idioma da publicação (ex. pt - Português, es - Espanhol)
type	tipo do documento
pid	identificador da publicação
publication_year	ano de publicação do artigo
sponsor	financiador
aff_country	código do país de afiliação do autor
aff_institution	instituição de afiliação do autor
volume	volume do artigo
issue	número do artigo
elocation	elocation
doi	número DOI
issn	ISSN da revista
in	código da coleção SciELO (ex. scl - Brasil, col - Colômbia)
use_license	código da licença de uso do artigo

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

Todo o conteúdo de www.scielo.org, exceto onde está identificado, está licenciado sob uma Licença Creative Commons.
saiba mais »